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They can increase oxidative stress and inflammation, disrupt the gut microbiome, and impact the methylation pathway

10.1152/ajpendo.00464.2009 14 PeriK.AbranD.HabiA.AbribatT

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Some patients may require more frequent administration, but this should only be adjusted under clinical supervision after excluding other causes of persistent symptoms

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Also, the vit-D supplementation could activate VDR function, regulate Ca 2+ flux, reset cardiac muscle contractility, and help reduce risks of myocardial infarction in COVID-19 and PASC patients